Covid: Medical experts to study the real-world effectiveness of Covishield and Covaxin -GS Mudur

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published Published on May 30, 2021   modified Modified on May 31, 2021

-The Telegraph

Researchers will document the vaccination status of infected patients admitted with severe disease at 11 sites across the country

Medical researchers have launched India’s first study to measure the real-world effectiveness of Covishield and Covaxin by documenting the vaccination status of Covid-19 patients admitted with severe disease at 11 sites across the country.

The study by the National Institute of Epidemiology (NIE), Chennai, a unit of the Indian Council of Medical Research (ICMR), will compare the vaccination status of 1,300 patients with severe Covid-19 and 2,600 people who test negative for Covid-19.

“If the vaccines are effective, we’d expect to find the proportion of unvaccinated people to be significantly higher in patients with severe disease than in people who test negative for Covid-19,” Tarun Bhatnagar, a senior scientist at the NIE and principal investigator of the study, told The Telegraph.

The fractions of those vaccinated among the 1,300 hospitalised patients and the 2,600 Covid-19 negative people will yield estimates of effectiveness.

For example, if 1,000 of the 1,300 with severe disease are unvaccinated and only 200 of the 2,600 negative controls are unvaccinated, that would imply vaccine efficacy. However, if 650 of the 1,300 with severe disease are unvaccinated and 1,300 of 2,600 negative controls are unvaccinated, that would mean there is no observed efficacy.

The NIE will collaborate with the All India Institutes of Medical Sciences in Delhi, Bhubaneswar, Jodhpur and Rishikesh and seven other hospitals in Chennai, Delhi, Kochi, Mysore, Nagpur, Puducherry, and Surat to recruit the study participants from different geographical regions.

The ICMR’s National Institute of Virology, Pune, will sequence the genomes of the viruses from the Covid-19 positive cases to analyse the effectiveness of vaccines against different variants of the virus circulating in India.

The study represents the first systematic effort to determine how well Covishield and Covaxin work in real-life conditions in India since the country launched its Covid-19 vaccination campaign in January.

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The Telegraph, 30 May, 2021, https://www.telegraphindia.com/india/coronavirus-outbreak-real-life-test-for-covishield-and-covaxin/cid/1817149


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